主要論文

1. Estradiol Facilitates Functional Integration of iPSC-Derived Dopaminergic Neurons into Striatal Neuronal Circuits via Activation of Integrin α5β1. Nishimura K, Doi D, Samata B, Murayama S, Tahara T, Onoe H, Takahashi J. Stem Cell Reports. 2016 Mar 16. PubMed
2. Detection of Cyclooxygenase-1 in Activated Microglia During Amyloid Plaque Progression: PET Studies in Alzheimer's Disease Model Mice. Shukuri M, Mawatari A, Ohno M, Suzuki M, Doi H, Watanabe Y, Onoe H. J Nucl Med. 2016 Feb;57(2):291-6. PubMed
3. A novel (11)C-labeled thymidine analog, [(11)C]AZT, for tumor imaging by positron emission tomography. Tahara T, Zhang Z, Ohno M, Hirao Y, Hosaka N, Doi H, Suzuki M, Onoe H. EJNMMI Res. 2015 Dec;5(1):124. PubMed
4. Increase in [18F]-Fluoroacetate Uptake in Patients With Chronic Hemodynamic Cerebral Ischemia. Yamauchi H, Kagawa S, Kishibe Y, Takahashi M, Nishii R, Mizuma H, Takahashi K, Onoe H, Higashi T. Stroke. 2015 Sep;46(9):2669-72. PubMed
5. Positron emission tomography imaging of the social brain of common marmosets. Yokoyama C, Onoe H. Neurosci Res. 2015 Apr;93:82-90. PubMed
6. Temporal plasticity involved in recovery from manual dexterity deficit after motor cortex lesion in macaque monkeys. Murata Y, Higo N, Hayashi T, Nishimura Y, Sugiyama Y, Oishi T, Tsukada H, Isa T, Onoe H. J Neurosci. 2015 Jan 7;35(1):84-95. PubMed
7. A voxel-based analysis of brain activity in high-order trigeminal pathway in the rat induced by cortical spreading depression. Cui Y, Toyoda H, Sako T, Onoe K, Hayashinaka E, Wada Y, Yokoyama C, Onoe H, Kataoka Y, Watanabe Y. Neuroimage. 2015 Mar;108:17-22. PubMed
8. Pd0-mediated rapid cross-coupling reactions, the rapid C-[11C]methylations, revolutionarily advancing the syntheses of short-lived PET molecular probes. Suzuki M, Doi H, Koyama H, Zhang Z, Hosoya T, Onoe H, Watanabe Y. Chem Rec. 2014 Jun;14(3):516-41. PubMed
9. Human whole-body biodistribution and dosimetry of a new PET tracer, [(11)C]ketoprofen methyl ester, for imagings of neuroinflammation. Ohnishi A, Senda M, Yamane T, Sasaki M, Mikami T, Nishio T, Ikari Y, Nishida H, Shukuri M, Takashima T, Mawatari A, Doi H, Watanabe Y, Onoe H. Nucl Med Biol. 2014 Aug;41(7):594-9. PubMed
10. Whole-brain imaging with single-cell resolution using chemical cocktails and computational analysis. Susaki EA, Tainaka K, Perrin D, Kishino F, Tawara T, Watanabe TM, Yokoyama C, Onoe H, Eguchi M, Yamaguchi S, Abe T, Kiyonari H, Shimizu Y, Miyawaki A, Yokota H, Ueda HR. Cell. 2014 Apr 24;157(3):726-39. PubMed
11. 11C-cetrozole: an improved C-11C-methylated PET probe for aromatase imaging in the brain. Takahashi K, Hosoya T, Onoe K, Doi H, Nagata H, Hiramatsu T, Li XL, Watanabe Y, Wada Y, Takashima T, Suzuki M, Onoe H, Watanabe Y. J Nucl Med. 2014 May;55(5):852-7. PubMed
12. A possible mechanism of the nucleus accumbens and ventral pallidum 5-HT1B receptors underlying the antidepressant action of ketamine: a PET study with macaques. Yamanaka H, Yokoyama C, Mizuma H, Kurai S, Finnema SJ, Halldin C, Doi H, Onoe H. Transl Psychiatry. 2014 Jan 7;4:e342. PubMed
13. Direct comparison of autologous and allogeneic transplantation of iPSC-derived neural cells in the brain of a non-human primate. Morizane A, Doi D, Kikuchi T, Okita K, Hotta A, Kawasaki T, Hayashi T, Onoe H, Shiina T, Yamanaka S, Takahashi J. Stem Cell Reports. 2013 Sep 26;1(4):283-92. PubMed
14. Neuroimaging for optimization of stem cell therapy in Parkinson's disease. Hayashi T, Onoe H. Expert Opin Biol Ther. 2013 Dec;13(12):1631-8. PubMed
15. Assessment of radioligands for PET imaging of cyclooxygenase-2 in an ischemic neuronal injury model. Ji B, Kumata K, Onoe H, Kaneko H, Zhang MR, Seki C, Ono M, Shukuri M, Tokunaga M, Minamihisamatsu T, Suhara T, Higuchi M. Brain Res. 2013 Oct 2;1533:152-62. PubMed
16. Na+/H+ exchanger inhibitor augments hyperosmolarity-induced vasoconstriction by enhancing actin polymerization. Sasahara T, Yayama K, Tahara T, Onoe H, Okamoto H. Vascul Pharmacol. 2013 Nov-Dec;59(5-6):120-6. PubMed
17. A conformationally fixed analog of the peptide mimic Grb2-SH2 domain: synthesis and evaluation against the A431 cancer cell. Iwata T, Tanaka K, Tahara T, Nozaki S, Onoe H, Watanabe Y, Fukase K. Mol Biosyst. 2013 May;9(5):1019-25. PubMed
18. Dorsolateral prefrontal and orbitofrontal cortex interactions during self-control of cigarette craving. Hayashi T, Ko JH, Strafella AP, Dagher A. Proc Natl Acad Sci U S A. 2013 Mar 12;110(11):4422-7. PubMed
19. Kinetics of neurodegeneration based on a risk-related biomarker in animal model of glaucoma. Hayashi T, Shimazawa M, Watabe H, Ose T, Inokuchi Y, Ito Y, Yamanaka H, Urayama S, Watanabe Y, Hara H, Onoe H. Mol Neurodegener. 2013 Jan 18;8:4. PubMed
20. The selective metabotropic glutamate 2/3 receptor agonist MGS0028 reverses psychomotor abnormalities and recognition memory deficits in mice lacking the pituitary adenylate cyclase-activating polypeptide. Ago Y, Hiramatsu N, Ishihama T, Hazama K, Hayata-Takano A, Shibasaki Y, Shintani N, Hashimoto H, Kawasaki T, Onoe H, Chaki S, Nakazato A, Baba A, Takuma K, Matsuda T. Behav Pharmacol. 2013 Feb;24(1):74-7. PubMed
21. Reduction of [11C](+)3-MPB binding in brain of chronic fatigue syndrome with serum autoantibody against muscarinic cholinergic receptor. Yamamoto S, Ouchi Y, Nakatsuka D, Tahara T, Mizuno K, Tajima S, Onoe H, Yoshikawa E, Tsukada H, Iwase M, Yamaguti K, Kuratsune H, Watanabe Y. PLoS One. 2012;7(12):e51515. PubMed
22. Autologous mesenchymal stem cell-derived dopaminergic neurons function in parkinsonian macaques. Hayashi T, Wakao S, Kitada M, Ose T, Watabe H, Kuroda Y, Mitsunaga K, Matsuse D, Shigemoto T, Ito A, Ikeda H, Fukuyama H, Onoe H, Tabata Y, Dezawa M. J Clin Invest. 2013 Jan;123(1):272-84. PubMed
23. Induction of amyloid-β(1-42) in the retina and optic nerve head of chronic ocular hypertensive monkeys. Ito Y, Shimazawa M, Tsuruma K, Mayama C, Ishii K, Onoe H, Aihara M, Araie M, Hara H. Mol Vis. 2012;18:2647-57. PubMed
24. The action site of the synthetic kainoid (2S,3R,4R)-3-carboxymethyl-4-(4-methylphenylthio)pyrrolidine-2-carboxylic acid (PSPA-4), an analogue of Japanese mushroom poison acromelic acid, for allodynia (tactile pain). Miyazaki S, Minami T, Mizuma H, Kanazawa M, Doi H, Matsumura S, Lu J, Onoe H, Furuta K, Suzuki M, Ito S. Eur J Pharmacol. 2013 Jun 15;710(1-3):120-7. PubMed
25. Functional annotation of genes differentially expressed between primary motor and prefrontal association cortices of macaque brain. Kojima T, Higo N, Sato A, Oishi T, Nishimura Y, Yamamoto T, Murata Y, Yoshino-Saito K, Onoe H, Isa T. Neurochem Res. 2013 Jan;38(1):133-40. PubMed
26. Metabotropic glutamate 2/3 receptor antagonists improve behavioral and prefrontal dopaminergic alterations in the chronic corticosterone-induced depression model in mice. Ago Y, Yano K, Araki R, Hiramatsu N, Kita Y, Kawasaki T, Onoe H, Chaki S, Nakazato A, Hashimoto H, Baba A, Takuma K, Matsuda T. Neuropharmacology. 2013 Feb;65:29-38. PubMed
27. Imaging epigenetic regulation by histone deacetylases in the brain using PET/MRI with ¹⁸F-FAHA. Yeh HH, Tian M, Hinz R, Young D, Shavrin A, Mukhapadhyay U, Flores LG, Balatoni J, Soghomonyan S, Jeong HJ, Pal A, Uthamanthil R, Jackson JN, Nishii R, Mizuma H, Onoe H, Kagawa S, Higashi T, Fukumitsu N, Alauddin M, Tong W, Herholz K, Gelovani JG. Neuroimage. 2013 Jan 1;64:630-9. PubMed
28. Evaluation of dopamine D₂/D₃ and serotonin 5-HT₂A receptor occupancy for a novel antipsychotic, lurasidone, in conscious common marmosets using small-animal positron emission tomography. Nakazawa S, Yokoyama C, Nishimura N, Horisawa T, Kawasaki A, Mizuma H, Doi H, Onoe H. Psychopharmacology (Berl). 2013 Jan;225(2):329-39. PubMed
29. The food reaching test: a sensitive test of behavioral improvements by deep brain stimulation in MPTP-treated monkey. Asakawa T, Sugiyama K, Akamine S, Yokoyama C, Shukuri M, Mizuma H, Tsukada H, Onoe H, Namba H. Neurosci Res. 2012 Oct;74(2):122-8. PubMed
30. Linkage between the midline cortical serotonergic system and social behavior traits: positron emission tomography studies of common marmosets. Yokoyama C, Kawasaki A, Hayashi T, Onoe H. Cereb Cortex. 2013 Sep;23(9):2136-45. PubMed
31. Increase of 20-HETE synthase after brain ischemia in rats revealed by PET study with 11C-labeled 20-HETE synthase-specific inhibitor. Kawasaki T, Marumo T, Shirakami K, Mori T, Doi H, Suzuki M, Watanabe Y, Chaki S, Nakazato A, Ago Y, Hashimoto H, Matsuda T, Baba A, Onoe H. J Cereb Blood Flow Metab. 2012 Sep;32(9):1737-46. PubMed
32. Disruption of programmed masticatory movements in unilateral MPTP-treated monkeys as a model of jaw movement abnormality in Parkinson's disease. Adachi K, Kobayashi M, Kawasaki T, Yokoyama C, Waddington JL, Sakagami H, Onoe H, Koshikawa N. J Neural Transm. 2012 Aug;119(8):933-41. PubMed
33. Prolonged maturation culture favors a reduction in the tumorigenicity and the dopaminergic function of human ESC-derived neural cells in a primate model of Parkinson's disease. Doi D, Morizane A, Kikuchi T, Onoe H, Hayashi T, Kawasaki T, Motono M, Sasai Y, Saiki H, Gomi M, Yoshikawa T, Hayashi H, Shinoyama M, Refaat MM, Suemori H, Miyamoto S, Takahashi J. Stem Cells. 2012 May;30(5):935-45. PubMed
34. An alteration in the lateral geniculate nucleus of experimental glaucoma monkeys: in vivo positron emission tomography imaging of glial activation. Shimazawa M, Ito Y, Inokuchi Y, Yamanaka H, Nakanishi T, Hayashi T, Ji B, Higuchi M, Suhara T, Imamura K, Araie M, Watanabe Y, Onoe H, Hara H. PLoS One. 2012;7(1):e30526. PubMed
35. The selective metabotropic glutamate 2/3 receptor agonist MGS0028 reverses isolation rearing-induced abnormal behaviors in mice. Ago Y, Araki R, Yano K, Kawasaki T, Chaki S, Nakazato A, Onoe H, Hashimoto H, Baba A, Takuma K, Matsuda T. J Pharmacol Sci. 2012;118(2):295-8. PubMed
36. Quantification of regional cerebral blood flow in rats using an arteriovenous shunt and micro-PET. Ose T, Watabe H, Hayashi T, Kudomi N, Hikake M, Fukuda H, Teramoto N, Watanabe Y, Onoe H, Iida H. Nucl Med Biol. 2012 Jul;39(5):730-41. PubMed
37. Template-assisted and self-activating clicked peptide as a synthetic mimic of the SH2 domain. Tanaka K, Shirotsuki S, Iwata T, Kageyama C, Tahara T, Nozaki S, Siwu ER, Tamura S, Douke S, Murakami N, Onoe H, Watanabe Y, Fukase K. ACS Chem Biol. 2012 Apr 20;7(4):637-45. PubMed
38. Use of [18F]FDOPA-PET for in vivo evaluation of dopaminergic dysfunction in unilaterally 6-OHDA-lesioned rats. Kyono K, Takashima T, Katayama Y, Kawasaki T, Zochi R, Gouda M, Kuwahara Y, Takahashi K, Wada Y, Onoe H, Watanabe Y. EJNMMI Res. 2011 Nov 10;1(1):25. PubMed
39. Neural substrates for the motivational regulation of motor recovery after spinal-cord injury. Nishimura Y, Onoe H, Onoe K, Morichika Y, Tsukada H, Isa T. PLoS One. 2011;6(9):e24854. PubMed
40. In vivo expression of cyclooxygenase-1 in activated microglia and macrophages during neuroinflammation visualized by PET with 11C-ketoprofen methyl ester. Shukuri M, Takashima-Hirano M, Tokuda K, Takashima T, Matsumura K, Inoue O, Doi H, Suzuki M, Watanabe Y, Onoe H. J Nucl Med. 2011 Jul;52(7):1094-101. PubMed
41. Developmental changes in P-glycoprotein function in the blood-brain barrier of nonhuman primates: PET study with R-11C-verapamil and 11C-oseltamivir. Takashima T, Yokoyama C, Mizuma H, Yamanaka H, Wada Y, Onoe K, Nagata H, Tazawa S, Doi H, Takahashi K, Morita M, Kanai M, Shibasaki M, Kusuhara H, Sugiyama Y, Onoe H, Watanabe Y. J Nucl Med. 2011 Jun;52(6):950-7. PubMed
42. Activation of metabotropic glutamate 2/3 receptors attenuates methamphetamine-induced hyperlocomotion and increase in prefrontal serotonergic neurotransmission. Ago Y, Araki R, Yano K, Hiramatsu N, Kawasaki T, Chaki S, Nakazato A, Onoe H, Hashimoto H, Baba A, Takuma K, Matsuda T. Psychopharmacology (Berl). 2011 Oct;217(3):443-52. PubMed
43. Increase in hypothalamic aromatase in macaque monkeys treated with anabolic-androgenic steroids: PET study with [11C]vorozole. Takahashi K, Onoe K, Doi H, Nagata H, Yamagishi G, Hosoya T, Tamura Y, Wada Y, Yamanaka H, Yokoyama C, Mizuma H, Takashima T, Bergström M, Onoe H, Långström B, Watanabe Y. Neuroreport. 2011 May 11;22(7):326-30. PubMed
44. Differential regional distribution of phosphorylated tau and synapse loss in the nucleus accumbens in tauopathy model mice. Kambe T, Motoi Y, Inoue R, Kojima N, Tada N, Kimura T, Sahara N, Yamashita S, Mizoroki T, Takashima A, Shimada K, Ishiguro K, Mizuma H, Onoe H, Mizuno Y, Hattori N. Neurobiol Dis. 2011 Jun;42(3):404-14. PubMed
45. Practical synthesis of precursor of [N-methyl-11C]vorozole, an efficient PET tracer targeting aromatase in the brain. Takahashi K, Yamagishi G, Hiramatsu T, Hosoya A, Onoe K, Doi H, Nagata H, Wada Y, Onoe H, Watanabe Y, Hosoya T. Bioorg Med Chem. 2011 Feb 15;19(4):1464-70. PubMed
46. Involvement of a phosphorylation-mediated pathway to regulate the function of NSPL1 in exercise. Ikemoto T, Suzuki M, Onoe H. J Vet Med Sci. 2011 Jun;73(6):733-8. PubMed
47. Involvement of endoplasmic reticulum stress on neuronal cell death in the lateral geniculate nucleus in the monkey glaucoma model. Ito Y, Shimazawa M, Inokuchi Y, Yamanaka H, Tsuruma K, Imamura K, Onoe H, Watanabe Y, Aihara M, Araie M, Hara H. Eur J Neurosci. 2011 Mar;33(5):843-55. PubMed
48. Survival of human induced pluripotent stem cell-derived midbrain dopaminergic neurons in the brain of a primate model of Parkinson's disease. Kikuchi T, Morizane A, Doi D, Onoe H, Hayashi T, Kawasaki T, Saiki H, Miyamoto S, Takahashi J. J Parkinsons Dis. 2011;1(4):395-412. PubMed
49. Medial orbitofrontal cortex is associated with fatigue sensation. Tajima S, Yamamoto S, Tanaka M, Kataoka Y, Iwase M, Yoshikawa E, Okada H, Onoe H, Tsukada H, Kuratsune H, Ouchi Y, Watanabe Y. Neurol Res Int. 2010;2010:671421. PubMed
50. Increased binding of cortical and hippocampal group II metabotropic glutamate receptors in isolation-reared mice. Kawasaki T, Ago Y, Yano K, Araki R, Washida Y, Onoe H, Chaki S, Nakazato A, Hashimoto H, Baba A, Takuma K, Matsuda T. Neuropharmacology. 2011 Feb-Mar;60(2-3):397-404. PubMed
51. Cortical activation during color discrimination task in macaques as revealed by positron emission tomography. Katsuyama N, Imamura K, Onoe H, Tanaka HK, Onoe K, Tsukada H, Watanabe Y. Neurosci Lett. 2010 Nov 5;484(3):168-73. PubMed
52. Establishment of in vivo brain imaging method in conscious mice. Mizuma H, Shukuri M, Hayashi T, Watanabe Y, Onoe H. J Nucl Med. 2010 Jul;51(7):1068-75. PubMed
53. SPP1 is expressed in corticospinal neurons of the macaque sensorimotor cortex. Higo N, Sato A, Yamamoto T, Nishimura Y, Oishi T, Murata Y, Onoe H, Yoshino-Saito K, Tsuboi F, Takahashi M, Isa T, Kojima T. J Comp Neurol. 2010 Jul 1;518(13):2633-44. PubMed
54. Electrocyclization-based labeling allows efficient in vivo imaging of cellular trafficking. Tanaka K, Minami K, Tahara T, Fujii Y, Siwu ER, Nozaki S, Onoe H, Yokoi S, Koyama K, Watanabe Y, Fukase K. ChemMedChem. 2010 Jun 7;5(6):841-5. PubMed
55. Mapping of serotonin transporters by positron emission tomography with [11C]DASB in conscious common marmosets: comparison with rhesus monkeys. Yokoyama C, Yamanaka H, Onoe K, Kawasaki A, Nagata H, Shirakami K, Doi H, Onoe H. Synapse. 2010 Aug;64(8):594-601. PubMed
56. General method for the (11)C-labeling of 2-arylpropionic acids and their esters: construction of a PET tracer library for a study of biological events involved in COXs expression. Takashima-Hirano M, Shukuri M, Takashima T, Goto M, Wada Y, Watanabe Y, Onoe H, Doi H, Suzuki M. Chemistry. 2010 Apr 12;16(14):4250-8. PubMed

受賞歴

2015年

第74回日本医学放射線学会総会　Platinum Medal受賞 (西井 龍一)

2014年

第9回日本分子イメージング学会 最優秀発表賞 (高良 沙幸)

2013年

第8回日本分子イメージング学会 最優秀発表賞 (水間 広)

2012年

第7回日本分子イメージング学会 最優秀発表賞 (川崎 俊之)

2012年

理化学研究所 研究奨励賞 (水間 広)

2011年

第6回日本分子イメージング学会 最優秀発表賞 (宿里 充穂)

2010年

SNM 2010 Annual Meeting ポスター2等賞 (水間 広)

2007年

第44回エルウイン・フォン・ベルツ賞1等賞(尾上 浩隆)

1989年

第26回エルウイン・フォン・ベルツ賞1等賞(尾上 浩隆)